2-(5-Tetrazolyl)phenylboronic acid

2-(5-Tetrazolyl)phenylboronic acid - Names and Identifiers

Name	2-(2H-TETRAZOL-5-YL)-PHENYLBORONIC ACID
Synonyms	2-(5-Tetrazolyl)phenylboronic acid 2-(TETRAZOL-5-YL)PHENYLBORONIC ACID 2-(TETRAZOL-5-YL)BENZENEBORONIC ACID 2-(1H-Tetrazol-5-yl)phenylboronic acid 2-(1H-Tetrazol-5-yl)benzeneboronic acid 2-(2H-TETRAZOL-5-YL)-PHENYLBORONIC ACID Boronic acid, B-[2-(2H-tetrazol-5-yl)phenyl]-
CAS	155884-01-8
InChI	InChI=1/C7H7BN4O2/c13-8(14)6-4-2-1-3-5(6)7-9-11-12-10-7/h1-4,13-14H,(H,9,10,11,12)
InChIKey	GVRXWYFECKHTSJ-UHFFFAOYSA-N

2-(5-Tetrazolyl)phenylboronic acid - Physico-chemical Properties

Molecular Formula	C7H7BN4O2
Molar Mass	189.97
Density	1.51
Melting Point	148-152°C
Boling Point	507.1±60.0 °C(Predicted)
Flash Point	260.5°C
Vapor Presure	4.17E-11mmHg at 25°C
pKa	4.35±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.641
MDL	MFCD06796325
Use	Intermediate

2-(5-Tetrazolyl)phenylboronic acid - Risk and Safety

Risk Codes	R36 - Irritating to the eyes R22 - Harmful if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
Hazard Note	Irritant

2-(5-Tetrazolyl)phenylboronic acid - Introduction

Tschasartan is a commonly used high blood pressure drug, its chemical name is 2-isobutyl-4-midoyl zinc chloride. The properties of 2-(2H-TETRAZOL-5-YL)-PHENYLBORONIC ACID include the following:

1. Appearance: 2-(2H-TETRAZOL-5-YL)-PHENYLBORONIC ACID is a white crystalline solid.

2. Stability: It is relatively stable at room temperature, but may decompose under conditions such as high temperature, humidity and light.

3. Solubility: 2-(2H-TETRAZOL-5-YL)-PHENYLBORONIC ACID is soluble in water and some common organic solvents, such as ethanol and acetone.

2-(2H-TETRAZOL-5-YL)-PHENYLBORONIC ACID is mainly used as a pharmaceutical intermediate for the synthesis of zdisartan, an angiotensin II receptor antagonist. By blocking the angiotensin Ⅱ receptor, Tschisatan helps lower blood pressure and reduce vasoconstriction, thereby playing a role in the treatment of hypertension and heart failure.

The preparation method of 2-(2H-TETRAZOL-5-YL)-PHENYLBORONIC ACID mainly has the following steps: first, 2-piperidone is reacted with zinc chloride to obtain 2-chloroperidone; Then, the reaction of 2-chloropiperidone with N-isobutyllithium gives 2-(2H-TETRAZOL-5-YL)-PHENYLBORONIC ACID.

When using and preparing 2-(2H-TETRAZOL-5-YL)-PHENYLBORONIC ACID, the following safety information should be noted:

1. Avoid contact with skin and eyes, can wear protective gloves and goggles and other personal protective equipment.

2. Keep the operating environment well ventilated, avoid inhalation of gas or solvent vapor.

3. Storage should be away from fire sources, heat sources and oxidants, keep the container closed, dry and dark.

4. If contact occurs, immediately flush the affected area with plenty of water and seek medical attention.

When using 2-(2H-TETRAZOL-5-YL)-PHENYLBORONIC ACID, the appropriate laboratory practices should be followed to ensure safety and efficiency. At the same time, care must be taken to operate only under suitable laboratory conditions to avoid potential hazards. It is recommended to operate under the guidance of professionals.

Last Update：2024-04-09 21:21:28